An algorithm to personalise the diagnosis of recurrent implantation failure based on theoretical cumulative implantation rate
نویسندگان
چکیده
Abstract Recurrent implantation failure (RIF) is an imprecisely defined disorder lacking a robust scientific basis. The incomplete understanding of RIF provides significant diagnostic and therapeutic challenges, better the underlying issues necessary to improve outcomes. We propose novel concept termed ‘Theoretical Cumulative Implantation Rate’, calculation which based on objective data, define whether patient should be diagnosed with RIF. An updated definition assist counselling planning research studies, more precise standardised, well overdue.
منابع مشابه
I-24: Recurrent Implantation Failure
Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...
متن کاملOnm-8: Recurrent Implantation Failure in IVF/ICSI Cycle
The success of assisted reproduction, although gradually increasing over the years, is still less than satisfactory. Many couples have benefited from this treatment; many have also been left frustrated following multiple failed attempts (Bulent Urman et al. 2005). Repeated implantation failure (RIF), defined as three or more failed IVF attempts or failure of IVF after cumula- Abstracts of the 5...
متن کاملI-40: Implantation Failure
Background: The process of implantation involves the interaction of the human embryo and the uterine epithelium. Failure of implantation is a major reason for infertility in women and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Management of repeated implantation failure despite transfer of good-quality embryos still rema...
متن کاملI-24: The Role of Interleukins, Integrins and Other Proteins in Recurrent Implantation Failure
Embryo implantation represents the most critical step of the reproductive process in many species. Inadequate uterine receptivity is responsible for approximately two-thirds of implantation failures. The cell adhesion molecule (CAM) such as integrins, cadherins, selectins and immunoglobulins intervene to ensure adhesiveness between the embryo and the endometrium. Some recent studies indicate th...
متن کاملPolymorphism of Genes and Implantation Failure
Implantation failure is the most frequent cause of pregnancy loss in couples who try to conceive, either in a natural way or using assisted reproductive techniques (ART). Identify the precise mechanisms of implantation failure can lead to identify couples at risk and also providing appropriate therapeutic options to affected couples. Despite the high prevalence of this disorder, a few causing f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Reproduction
سال: 2021
ISSN: ['1460-2350', '0268-1161']
DOI: https://doi.org/10.1093/humrep/deab091